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葡京集团与工程人员概览
程伟
时间:2017年12月02日 16:23来源: 点击数:

北京大学药学院副研究员,硕士研究生导师,中国药学会海洋药物专业委员会委员


联系方式

电话:+86-10-82805746

E-mail: chengwei@bjmu.edu.cn


教育背景

2018/09-2020/09  美国加州大学洛杉矶分校,化学与生物工程系,访问学者,合作导师:Prof. Yi Tang

2006/09-2009/06,中国医学科学院药物研究所,药物化学专业,博士,导师:石建功教授

2003/09-2006/06,河北医科大学,药学院,药物化学专业,硕士,导师:张嫡群教授

1999/09-2003/06,河北医科大学,药学院,学士


研究领域

海洋天然药物化学


工作经历

2009/08-至今,北京大学,药学院天然药物学系


主持或参加科研项目情况

1.基于海洋天然产物抗污生态特征的抗细菌生物膜功能分子的发现

  (国家自然科学基金面上项目,2017/01-2020/12,项目负责人)

2.海绵Leucetta chagosensis中特征性咪唑生物碱及其抗肿瘤活性研究

  (北京市自然科学基金面上项目,2017/01-2019/12,项目负责人)

3. Iotrochota属海绵及其内生菌中含氮化合物及其抗肿瘤活性研究

  (国家自然科学基金青年基金,2014/01-2016/12,项目负责人)

4. 苯骈噁嗪酮类衍生物的抗乙肝病毒生物活性及构效关系研究

  (教育部博士点基金,2011/01-2013/12,项目负责人)

5. 环境胁迫海洋生物产生的新药源分子研究

  (国家自然科学基金重大项目,2020/01-2024/12,子课题负责人)

6. 深海动植物来源候选药物系统成药性评价

  (科技部重点专项课题,2018/08-2021/12,子课题负责人)


代表性研究论文

1. Wei Cheng, Mengbin Chen, Masao Ohashi, Yi Tang*. Biosynthesis of Terpenoid–Pyrrolobenzoxazine Hybrid Natural Product CJ-12662. Angew. Chem. Int. Ed., 2022, 61, e202116928.

2. Linan Xie, Xin Zang, Wei Cheng, Zhuan Zhang, Jiahai Zhou, Mengbin Chen, Yi Tang*. Harzianic Acid from Trichoderma afroharzianum Is a Natural Product Inhibitor of Acetohydroxyacid Synthase. J. Am. Chem. Soc., 2021, 143(25): 9575-9584.

3. Nicholas Liu, Elizabeth D. Abramyan1, Wei Cheng1, Bruno Perlatti, Colin J.B. Harvey, GeraldF. Bills, Yi Tang*. Targeted Genome Mining Reveals the Biosynthetic Gene Clusters of Natural Product CYP51 Inhibitors. J. Am. Chem. Soc., 2021, 143(16): 6043-6047.

4. Danielle A.Yee#, Thomas B.Kakule#,Wei Cheng#, Mengbin Chen, Christine T. Y. Chong, Yang Hai, Leibniz F. Hang, Yiu-Sun Hung, Nicholas Liu, Masao Ohashi, Ikechukwu C. Okorafor, Yongxiang Song, Mancheng Tang, Zhuan Zhang, Yi Tang*. Genome Mining of Alkaloidal Terpenoids from a Hybrid Terpene and Nonribosomal Peptide Biosynthetic Pathway. J. Am. Chem. Soc., 2020, 142(2): 710-714.

5. Jiru Wu, Xiaodan Li, Xingchen Guo, Zhongbin Cheng, Junjun Meng, Wei Cheng*, Wenhan Lin*. Briarane-type diterpenoids from a gorgonian coral Ellisella sp. With anti-HBV activities. Bioorganic chemistry, 2020, 105, 104423.

6. Xiaodan Li#, Hui Liu#, Wei Cheng#, Jie Wang, He Zhang, Fengmin Lu, Xiangmei Chen*, Wenhan Lin*. Junceellolide B, a novel inhibitor of Hepatitis B virus. Bioorganic & Medicinal Chemistry 2020, 28(16), 115603.

7. Junjun Meng#, Wei Cheng#, Hajar Heydari, Bin Wang, Kui Zhu, Belma Konuklugil, Wenhan Lin*. Sorbicillinoid-based Metabolites from a Sponge-derived Fungus Trichoderma saturnisporum. Marine Drugs, 2018, 16, doi:10.3390/md16070226.

8. Jingyuan Sun, JiruWu, Bang An, Nicole J. de Voogd, Wei Cheng*, Wenhan Lin*. Bromopyrrole Alkaloids with the Inhibitory Effects against the Biofilm Formation of Gram Negative Bacteria. Marine Drugs, 2018, 16, doi: 10.3390/md16010009.

9. Bang An, Fuling Yin, Nicole J. de Voogd, Xiaoguang Chen, Wei Cheng*, and Wenhan Lin*. Chagosendines A – C, New Metal Complexes of Imidazole Alkaloids from the Calcareous Sponge Leucetta chagosensis. Chemistry & Biodiversity, 2018, 15, doi: 10.1002/cbdv.201700481.

10. Wei Cheng, Ming Ji, Xiaodan Li, Jinwei Ren, Fuling Yin, Leen van Ofwegen, Siwang Yu, Xiaoguang Chen, Wenhan Lin*. Fragilolides A-Q, norditerpenoid and briarane diterpenoids from the gorgonian coral Junceella fragilis. Tetrahedron, 2017, 73, 2518-2528.

11. Wei Cheng, Zhen Liu, Yang Yu, Leen van Ofwegen, Peter Proksch, Siwang Yu*, Wenhan Lin*. An unusual spinaceamine-bearing pregnane from a soft coral Scleronephthya sp. inhibits the migration of tumor cells. Bioorganic & Medicinal Chemistry Letters, 2017, 27, 2736-2741.

12. Wei Cheng, Xiaodan Li, Fuling Yin, Leen van Ofwegen, and Wenhan Lin*. Halogenated Briarane Diterpenes with Acetyl Migration from the Gorgonian CoralJunceella fragilis. Chemistry & Biodiversity, 2017, 14, doi: 10.1002/cbdv.201700053

13. Wei Cheng, Jinwei Ren, Qixi Huang, Hailin Long, Hongwei Jin, Liangren Zhang, Huagang Liu, Leen van Ofwegen, Wenhan Lin*. Pregnane steroids from a gorgonian coral Subergorgia suberosa with anti-flu virus effects. Steroids, 2016, 108, 99-104.

14. Qixi Huang, Wei Cheng*, Hailin Long, Huagang Liu, Leen van Ofwegen, and Wenhan Lin*. Subergane-Type Sesquiterpenes from Gorgonian Coral Subergorgia suberosa with Antibacterial Activities. Helvetica Chimica Acta, 2015, 98, 1202-1209.

15. Wei Cheng, Dong Liu, Fengying Zhang, Qingying Zhang, Patchara Pedpradab, Peter Proksch, Hong Liang, Wenhan Lin*. Formamidobisabolene-based derivatives from a spongeAxinyssa sp. Tetrahedron, 2014, 70, 3576-3583.




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